Unable to enlist the orchestration

Hi,

I have deployed a proj from VS2010 and I have imported the bindings form msi file.

problem i m facing is " When i try to start the orch, its throwing an exception

Could not enlist orchestration xxxx.xxx. AssemblyLoadException exception occurred while the XLANG/s runtime enlisted a service

Error message:Failed to load assembly "C:\Users\xxx\AppData\Local\Temp\\BizTalkAssembly\c05326511a791076a49f6fef2ea941a1\xxx.dll"

Access to the path 'C:\Users\xxx\AppData\Local\Temp\\BizTalkAssembly\c05326511a791076a49f6fef2ea941a1\xxx.dll' is denied. (Microsoft.BizTalk.ExplorerOM)

but the User has admin rights in the system

And in the eventvwr i saw a msg like this

Unable to communicate with MessageBox BizTalkMsgBoxDb on SQL Instance SRIKANTH-W8. Error Code: 0x8004d00e. Possible reasons include: 
 1) The MessageBox is unavailable.
 2) The network link from this machine to the MessageBox is down.
 3) The DTC Configuration on either this local machine or the machine hosting this MessageBox is incorrect.

I checked all teh 3 but unable to find the reason for this exception.

Can you guys pls help me

Thanks,

Srikbob